Officers and paramedics were called to Defender Road in the city at 5.05am on Sunday following reports that a child was in need of medical attention.
The baby was taken to Southampton General Hospital, where he later died.
An 18-year-old woman and a 16-year-old boy have been arrested in connection with the death and remain in custody for questioning, a spokesman for Hampshire Police confirmed.
"Inquiries into the circumstances are ongoing," the spokesman added.
Both suspects are from Southampton.
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